Tsinghua Holdings Co Ltd ("Tsinghua Holdings") is a solely State-owned limited liability corporation approved by the State Council. In September 2003, to incorporate enterprises under its control, Tsinghua University funded Tsinghua Holdings with a registered capital of 2.5 billion yuan ($395.13 million). In 2017, the company ranked No 163 in Chinese Top 500 enterprises by revenue and No 7 by R&D intensity.

By making full use of Tsinghua University's scientific research advantages and talent resources, Tsinghua Holdings has been committed to the development path of industry-academia-research integration to meet both national and social demands. The company remains focused on technology innovation and services by insisting on its strategy of ecological structure, communities, and globalization. Driven by a combination of innovation, industry, and capital, it aims to help push ground-breaking ideas and findings from the lab into the market, incubate and invest in start-up tech companies, and make contributions to China's emergence as an innovation-driven country and the transformation of its mode of economic development.

Tsinghua Holdings operates in five specialized areas: advanced technologies (integrated circuitry, environmental protection, and healthcare); innovation services; sci-tech finance; creative and cultural industries; and online education. It has a number of affiliated comprehensive groups such as Tongfang Co Ltd, Tsinghua Unigroup, TusHoldings Co Ltd, and Chengzhi Shareholding Co Ltd, as well as subsidiaries including Tsinghua Holdings Habitat Development Group, Tsinghua University Press, CapitalBio Corporation, Tsinghua Holdings Group Finance Co Ltd, Tsinghua Holdings Nuclear, and MOOC-EN Education. In addition, it has fostered some leading companies in terms of industry segmentation, such as Nuctech, GSAFETY, cnki.net, THTI Holdings, and Tianjin Hwatsing Technology. To date, Tsinghua Holdings has held shares of many listed companies, including Tongfang Co Ltd (600100), Chengzhi Shareholdings Co Ltd. (000990), Unisplendour Co Ltd (000938), Unigroup Guoxin Co Ltd (002049), Tongfang Technovator (01206.HK), Tus-Guhan Group Corp Ltd (000590), Neo-Neon Holdings Limited (01868.HK), Tus-Sound (000826), Tus International (00872.HK), and GSAFETY (300523). 

As a Tsinghua University's platform to serve society, Tsinghua Holdings has been working on bringing Tsinghua University's scientific and technological achievements to the market and industries. By the end of 2016, Tsinghua Holdings had commercialized 56 national key scientific achievements and made breakthroughs in over 60 key technologies. It has been in charge of the industrialization of three of 16 National Science and Technology Major Projects. Tsinghua Holdings has made remarkable achievements in technology innovation and technology transformation, including the world's first high-temperature gas cooled reactor nuclear power plant ; a freight container inspection system which enjoys the biggest global market share; China's first public safety and emergency response system with complete and independent intellectual property rights; China's first 12-inch CMP equipment; the world first hereditary deafness gene test chip; and the operation of the biggest university science park in the world, China's first entrepreneurship street.